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Your Position: Home > IL-12 R beta 1

IL-12 R beta 1

Brief Information

Name:Interleukin-12 receptor
Target Synonym:Receptors, Interleukin-12
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:12
Lastest Research Phase:Approved

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Part of Bioactivity data

ILB-H5255-SPR
 IL-12 R beta 1 SPR

Human IL-12 R beta 1, Fc Tag (Cat. No. ILB-H5255) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (Cat. No. IL2-H4210) with an affinity constant of 2.06 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

ILB-H52E1-BLI
 IL-12 R beta 1 BLI

Loaded Biotinylated Human IL-12 R beta 1, His,Avitag (Cat. No. ILB-H52E1) on SA Biosensor, can bind ActiveMax® Human IL-12 ,Tag Free (Cat. No. IL2-H5210) with an affinity constant of 1.7 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

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Synonym Name

IL-12 R beta 1,IL12RB1,CD212,IL12R,IL12RB,IL-12RB1

Background

The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12 R beta 1(Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212. Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Ustekinumab biosimilar (Samsung Bioepis) SB-17; SB17 Approved Samsung Bioepis Co Ltd Pyzchiva EU Crohn Disease; Colitis, Ulcerative Samsung Bioepis Nl Bv 2024-04-19 Gastrointestinal Diseases; Skin Diseases; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Rheumatic Diseases; Inflammation; Crohn Disease; Plaque psoriasis Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
KLT-1101 KLT-1101 Phase 2 Clinical Kang Litai Pharmaceutical Co Ltd Solid tumours; Leukopenia; Thrombocytopenia; Melanoma; Sarcoma, Kaposi Details
Edodekin alfa RO 247472; YM 01C Phase 2 Clinical Wistar Institute, Valeant, F. Hoffmann-La Roche Ltd Hepatitis B; Melanoma; Bacterial Infections; Sarcoma, Kaposi; Leishmaniasis; Carcinoma, Squamous Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, Non-Hodgkin; Lymphoma; Asthma; Hepatitis C; Solid tumours; Breast Neoplasms; Neoplasms; Carcinoma, Ovarian Epithelial; Graft vs Host Disease; Squamous Cell Carcinoma of Head and Neck; Abdominal Neoplasms; Carcinoma, Renal Cell; Malaria; HIV Infections Details
IMNN-001 IMNN-001; phIL-12-005/PPC; GEN-1; EGEN-001 Phase 2 Clinical Expression Genetics Cystadenocarcinoma; Ovarian Neoplasms; Cystadenocarcinoma, Serous; Carcinoma, Ovarian Epithelial; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Endometrioid Details
RTX-224 RTX-224 Phase 2 Clinical Rubius Therapeutics Inc Solid tumours; Skin Melanoma; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Transitional Cell; Triple Negative Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details
SON-1010 SON-1010 Phase 2 Clinical Sonnet Biotherapeutics Inc Solid tumours; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Fallopian Tube Neoplasms Details
KB-707 KB707; KB-707 Phase 2 Clinical Krystal Biotech Inc Solid tumours; Skin Melanoma; Neoplasms; Lung Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung Details
ASP-9801 ASP-9801 Phase 1 Clinical Astellas Pharma Inc Solid tumours; Neoplasms; Neoplasm Metastasis Details
ANK-101 ANK101; ANK-101 Phase 1 Clinical Ankyra Therapeutics Inc Solid tumours; Soft Tissue Injuries; Skin Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung Details
CLN-617 CLN-617 Phase 1 Clinical Cullinan Therapeutics Inc Solid tumours Details
phIL12 GET Phase 1 Clinical Institute Of Oncology Ljubljana Carcinoma, Basal Cell Details
Encapsulated pancreatic cancer vaccine(Therapyx) PCX-12 Phase 1 Clinical TherapyX Inc Pancreatic Neoplasms Details

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